Leufolins A and B, potent butyrylcholinesterase-inhibiting flavonoid glucosides from Leucas urticifolia

Atia-tun-Noor; Itrat Fatima; Ijaz Ahmad; Abdul Malik; Nighat Afza; Lubna Iqbal; Mehreen Latif; Sher Bahadar Khan

doi:10.3390/12071447

Leufolins A and B, potent butyrylcholinesterase-inhibiting flavonoid glucosides from Leucas urticifolia

Molecules. 2007 Jul 19;12(7):1447-54. doi: 10.3390/12071447.

Authors

Atia-tun-Noor¹, Itrat Fatima, Ijaz Ahmad, Abdul Malik, Nighat Afza, Lubna Iqbal, Mehreen Latif, Sher Bahadar Khan

Affiliation

¹ International Centre for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.

Abstract

New flavonoidal glucosides leufolins A (1) and B (2), have been isolated from the ethyl acetate soluble fraction of the whole plants of Leucas urticifolia. Their structures were elucidated on the basis of extensive analysis of nuclear magnetic resonance (1D and 2D NMR) spectral data. Both of these compounds exhibited significant inhibitory potential against the enzyme butyrylcholinesterase.

MeSH terms

Amaranthaceae / chemistry*
Butyrylcholinesterase / metabolism*
Carbon Isotopes
Cholinesterase Inhibitors / pharmacology*
Flavonoids / chemistry
Flavonoids / isolation & purification*
Glucosides / chemistry
Glucosides / isolation & purification*
Magnetic Resonance Spectroscopy
Protons

Substances

Carbon Isotopes
Cholinesterase Inhibitors
Flavonoids
Glucosides
Protons
leufolin A
leufolin B
Butyrylcholinesterase